Human antibody library
Y-Biologics has securedthe world-class antibody library, Ymax-ABL, to develop therapeutic antibody for the disease-related target. As Ymax-ABL is naïve cDNA library which stems from cDNA from human B cells, immunogenicity and toxicity are low. It allows to select the good antibodies to various antigens due to the huge diversity (≥100billion). Y-Biologics has also secured synthetic library, which is the alternative to broaden the choice of antibody selection.
Biopanning technology is to select the hit antibody to antigen from antibody library and antibody selection is determined bythe binding affinity between antigen and antibody.
Variable regions of heavy and light of selected phage antibody are converted to Y-shaped antibody.
Automatic identification of human antibody binder
Y-Biologics set up stream process from colony picking to RF mapping by integration of colony picker, liquid handler, ELISA system, and high through-put electrophoresis system. Y-Biologics can handle up to 10,000 different clones in time.