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Products & Services Humanized Antibody

You can expect high therapeutic effect when you transfer the CDR(Complementary-Determining Region) from the variable region of therapeutically effective mouse-derived monoclonal antibody into human antibody backbone due to the minimized immunogenicity.

Outline of Humanization by CDR-Grafting

  • Mouse hybridoma
  • Cloning and sequencing of VH and VL
  • Identification of CDRs from VH and VL
  • Grafting of CDRs onto human germline VH and VL
  • Transient expression and affinity measurement of CDR-grafted humanized antibodies
  • Selection of CDR-grafted humanized antibody